What is kratom? The science behind Mitragyna's strange leaves
Kratom has become popular among opioid users trying to get clean. Meanwhile, researchers push forward as US regulators consider cracking down
The leaves of Mitragyna speciosa, kratom’s Latin name, have been used for centuries throughout Southeast Asia for all of the aforementioned properties. The plants grow wild in Malaysia, Thailand and Indonesia, with related species of the genus Mitragyna ranging as far as India and South Africa.
In the United States, kratom use has surged in the past decade amid the ongoing opioid crisis, which claims dozens of lives each day
Respiratory effects of oral mitragynine and oxycodone in a rodent model.
Compare the respiratory effects of oral mitragynine to oral oxycodone in rats for evaluating effects of opioids
Consistent with mitragynine’s pharmacology that includes partial µ-opioid receptor agonism with little recruitment of the respiratory depressant activating β-arrestin pathway, mitragynine produced no evidence of respiratory depression at doses many times higher than known to be taken by humans.
atai Life Sciences - Phase 1 trial of kratom-derived pharmaceutical
atai and Kures are poised to address two key factors underlying the opioid epidemic developing a potentially safer and more widely available alternative for both pain management and opioid maintenance therapy.
One of the leading therapeutic indicators of kratom is its analgesic effect. One study of Kratom users in Malaysia showed that 90% were using kratom as a substitute for opioids, with 84% reporting that kratom eased their opioid withdrawal symptoms.
Kratom-Pharmacology, Clinical Implications and Deep Review
The prevalence of kratom use appears to be increasing in Europe and North America, raising concerns for its possible development into a significant public health threat.
The body of scientific literature concerning kratom is expanding, but has not yet sufficiently characterized the nature and extent of the potential risks posed by kratom.
There is an increasing need for healthcare providers to be familiar with kratom and the management of patients who abuse it.
Kratom-Pharmacology, Clinical Implications and Deep Review - KRATOM LORDSkratomlords.com
The prevalence of kratom use appears to be increasing in Europe and North America, raising concerns for its possible development into a significant public health threat. The body of scientific literature concerning kratom is expanding, but has not yet sufficiently characterized the nature and extent of the potential risks posed by kratom.
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