Respiratory effects of oral mitragynine and oxycodone in a rodent model.
Compare the respiratory effects of oral mitragynine to oral oxycodone in rats for evaluating effects of opioids
Consistent with mitragynine’s pharmacology that includes partial µ-opioid receptor agonism with little recruitment of the respiratory depressant activating β-arrestin pathway, mitragynine produced no evidence of respiratory depression at doses many times higher than known to be taken by humans.
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