Imatinib 400 mg is a potent tyrosine kinase receptor inhibitor for platelet and stem cell growth factors, as well as c-Kit. Imatinib 400 mg tablet is able to inhibit proliferation and induce apoptosis of stromal neoplasm cells in the gastrointestinal tract that express kit mutations.

Imatinib 400 mg with a coating in the form of a shell may contain 50 mg of imatinib price tablet (used in the form of mesylate) and 65.2 mg of low-substituted hyprolosis, 0.285 mg of povidone, 21 mg of sodium carboxymethyl starch, 1.9 mg of colloidal silicon dioxide, and 1.035 mg of stearate magnesium. Imatinib 400 mg is a potent tyrosine kinase receptor inhibitor for platelet and stem cell growth factors, as well as c-Kit. Imatinib 400 mg tablet is able to inhibit proliferation and induce apoptosis of stromal neoplasm cells in the gastrointestinal tract that express kit mutations.

Indications for use

Imatinib tablet treatment is prescribed for chronic myeloid leukemia, as well as during the blastic crisis and in the acute phase. Most often, the drug is used in case of unsuccessful treatment with Interferon Alfa.

The drug is also used in adults with inoperable and/or metastatic stromal gastrointestinal tumors (GIST). Adjuvant therapy is performed after GIST resection.

Contraindications

The presence of hypersensitivity reactions to any of the components of Imatinib 400 mg.

There is no data on the safety and efficacy of use in children under 3 years of age.

With care, it is necessary to use the drug in patients with impaired liver function, since it is possible to enhance the effect of this antitumor agent.

Imatinib tablet Side effects

• rash;
• myalgia, muscle spasm;
• diarrhea, nausea, and vomiting;
• peripheral edema (usually occur with a diuretic or with a dose of imatinib 400 mg).

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