Therapeutic potential and liability of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.
Kratom, derived from the plant Mitragyna speciosa, is receiving increased attention as an alternative to traditional opiates and as a replacement therapy for opiate dependence.
The increasing use of kratom has emerged as a public health concern in the US.
atai Life Sciences - Phase 1 trial of kratom-derived pharmaceutical
atai and Kures are poised to address two key factors underlying the opioid epidemic developing a potentially safer and more widely available alternative for both pain management and opioid maintenance therapy.
One of the leading therapeutic indicators of kratom is its analgesic effect. One study of Kratom users in Malaysia showed that 90% were using kratom as a substitute for opioids, with 84% reporting that kratom eased their opioid withdrawal symptoms.
The Antidepressant-Like and Analgesic Effects of Kratom
Kratom employed as a traditional medicine to improve mood and relieve pain, has shown increased use in Europe and North America. Here, the dose-dependent effects of a purified alkaloid kratom extract on neuronal oscillatory systems function, analgesia, and antidepressant-like behaviour were evaluated and kratom-induced changes in ΔFosB expression determined.
Some people have experienced different effects, including weight loss. However, there are also users who report that kratom may be making them gain weight. But, is this possible? Does kratom cause weight gain? We’ll explore this subject in this article.
