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Hydrocodone M365 refers to a prescription opioid combination tablet containing hydrocodone and acetaminophen. It may be prescribed for pain when a healthcare professional determines that an opioid is appropriate. Because hydrocodone can cause drowsiness, dependence, misuse, and potentially dangerous breathing problems, it should be taken only as prescribed. Acetaminophen can also cause serious liver injury when excessive amounts are consumed. Avoid alcohol and other sedating medicines unless specifically approved by a healthcare professional. Never share prescription medication with another person. Keep it securely stored and follow appropriate disposal guidance. Seek emergency medical attention for severe breathing difficulty, extreme sleepiness, or loss of consciousness.