Dengue virus is an enveloped single-stranded positive-sense RNA virus, which belongs to the family of Flaviviridae. Dengue virus has approximately 11,000 nucleotides in length that encodes three structural (C, Env, M) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5). There are four different serotypes of dengue virus (DENV 1-4) and the classification is based on structural antigens that induce type-specific antibodies at the time of infection. Dengue fever is an arthropod-borne disease caused by the dengue virus (DENV), mainly transmitted by Aedes aegypti mosquitoes. Dengue fever is the most popular mosquito-borne disease in the world. The dengue virus mainly spreads in tropical and subtropical regions, including Southeast Asia, the Americas, Africa, the Western Pacific, and the Eastern Mediterranean.